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Literature summary for 1.4.3.4 extracted from

  • Lee, Y.; Ling, K.Q.; Lu, X.; Silverman, R.B.; Shepard, E.M.; Dooley, D.M.; Sayre, L.M.
    3-Pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases (2002), J. Am. Chem. Soc., 124, 12135-12143.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.252
-
3-phenyl-3-pyrroline pH 7.2, 30°C Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Bos taurus P56560
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phenyl-3-pyrroline + H2O + O2
-
Bos taurus 4-phenyl-2H-pyrrole + ? 4-phenyl-2H-pyrrole rapidly tautomerizes to 5-phenyl-2H-pyrrole ?
3-pyrroline + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases Bos taurus ? + H2O2 + NH3
-
?
pyrrolidine + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2
-
Bos taurus ? + H2O2 + NH3
-
?

Synonyms

Synonyms Comment Organism
MAO-B
-
Bos taurus
monoamine oxidase B
-
Bos taurus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
834
-
3-phenyl-3-pyrroline pH 7.2, 30°C Bos taurus

Cofactor

Cofactor Comment Organism Structure
flavin
-
Bos taurus