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Literature summary for 1.4.3.4 extracted from

  • Herraiz, T.; Chaparro, C.
    Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors (2005), Biochem. Biophys. Res. Commun., 326, 378-386.
    View publication on PubMed

Application

Application Comment Organism
medicine target for antidepressant and neuroprotective drugs Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
beta-carbolines competitive reversible and potent inhibitor Homo sapiens
harman
-
Homo sapiens
additional information cigarette smoke is a potent inhibitor of MAO-A. Inhibition is partly reversible, competitive. beta-Carboline alkaloids from cigarette smoke acting as potent reversible inhibitors may contribute to the MAO reduced activity produced by tobacco smoke in smokers; cigarette smoke is a potent inhibitor of MAO-B. Inhibition is partly reversible, competitive. Veta-carboline alkaloids from cigarette smoke acting as potent reversible inhibitors may contribute to the MAO reduced activity produced by tobacco smoke in smokers Homo sapiens
norharman competitive reversible and potent inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane
-
Homo sapiens 5741
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 30% lower activity of peripheral and brain MAO-A compared to smokers ?
-
?
additional information Homo sapiens the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 40% lower activity of peripheral and brain MAO-B compared to smokers ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + H2O + O2
-
Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
?
additional information the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 30% lower activity of peripheral and brain MAO-A compared to smokers Homo sapiens ?
-
?
additional information the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 40% lower activity of peripheral and brain MAO-B compared to smokers Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MAO-A
-
Homo sapiens
MAO-B
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00005554
-
harman pH 7.4, 37°C, monoamine oxidase A Homo sapiens
0.00112
-
norharman pH 7.4, 37°C, monoamine oxidase B Homo sapiens
0.0012
-
norharman pH 7.4, 37°C, monoamine oxidase A Homo sapiens