Application | Comment | Organism |
---|---|---|
medicine | target for antidepressant and neuroprotective drugs | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-carbolines | competitive reversible and potent inhibitor | Homo sapiens | |
harman | - |
Homo sapiens | |
additional information | cigarette smoke is a potent inhibitor of MAO-A. Inhibition is partly reversible, competitive. beta-Carboline alkaloids from cigarette smoke acting as potent reversible inhibitors may contribute to the MAO reduced activity produced by tobacco smoke in smokers; cigarette smoke is a potent inhibitor of MAO-B. Inhibition is partly reversible, competitive. Veta-carboline alkaloids from cigarette smoke acting as potent reversible inhibitors may contribute to the MAO reduced activity produced by tobacco smoke in smokers | Homo sapiens | |
norharman | competitive reversible and potent inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial outer membrane | - |
Homo sapiens | 5741 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 30% lower activity of peripheral and brain MAO-A compared to smokers | ? | - |
? | |
additional information | Homo sapiens | the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 40% lower activity of peripheral and brain MAO-B compared to smokers | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kynuramine + H2O + O2 | - |
Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
additional information | the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 30% lower activity of peripheral and brain MAO-A compared to smokers | Homo sapiens | ? | - |
? | |
additional information | the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 40% lower activity of peripheral and brain MAO-B compared to smokers | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Homo sapiens |
MAO-B | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00005554 | - |
harman | pH 7.4, 37°C, monoamine oxidase A | Homo sapiens | |
0.00112 | - |
norharman | pH 7.4, 37°C, monoamine oxidase B | Homo sapiens | |
0.0012 | - |
norharman | pH 7.4, 37°C, monoamine oxidase A | Homo sapiens |