Cloned (Comment) | Organism |
---|---|
quantitative real-time PCR expression analysis in different cells | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Rattus norvegicus | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-serine + H2O + O2 | Rattus norvegicus | - |
2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
additional information | Rattus norvegicus | the flavoenzyme catalyzes the oxidative deamination of neutral and basic D-amino acids to the corresponding 2-oxo acids and H2O2 with concomitant reduction of FAD | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | in lower brain stem and cerebellum, as well as type-1 astrocytes from cerebral cortex and the cerebellum | Rattus norvegicus | - |
astroglial cell | - |
Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
C6 glioma cell | glioma cells | Rattus norvegicus | - |
H4TG cell | a derivative of the H4-IIE-C3 rat hepatoma cell line | Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-serine + H2O + O2 | - |
Rattus norvegicus | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
additional information | the flavoenzyme catalyzes the oxidative deamination of neutral and basic D-amino acids to the corresponding 2-oxo acids and H2O2 with concomitant reduction of FAD | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 38500-39000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
DAO | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
additional information | metabolism of extracellular D-serine and effects of D-serine metabolites with pathophysiological role of DAO, overexpression of DAO in astroglial cells induces the enhanced cytotoxicity, reaction product beta-hydroxypyruvate also induces cell death, comprising apoptosis, in the astroglial cell, but not in the other cells derived from liver and kidney, overview | Rattus norvegicus |