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Literature summary for 1.4.3.3 extracted from

  • Verrall, L.; Burnet, P.W.; Betts, J.F.; Harrison, P.J.
    The neurobiology of D-amino acid oxidase and its involvement in schizophrenia (2009), Mol. Psychiatry, 15, 122-137.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme activity is increased in schizophrenia Homo sapiens

Application

Application Comment Organism
medicine the enzyme inhibition might have an therapeutic effect in schizophrenia treatment Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-serine + H2O + O2 Homo sapiens metabolizaation of the N-methyl D-aspartate receptor co-agonist 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
flavoprotein
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-serine + H2O + O2
-
Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?
D-serine + H2O + O2 metabolizaation of the N-methyl D-aspartate receptor co-agonist Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
DAO
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD flavoenzyme Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is increased in schizophrenia up

General Information

General Information Comment Organism
physiological function the enzyme modulates the function of the N-methyl D-aspartate receptor contributing to the involvement of the receptor signalling in schizophrenia Homo sapiens