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Literature summary for 1.4.3.3 extracted from

  • Ono, K.; Shishido, Y.; Park, H.K.; Kawazoe, T.; Iwana, S.; Chung, S.P.; Abou El-Magd, R.M.; Yorita, K.; Okano, M.; Watanabe, T.; Sano, N.; Bando, Y.; Arima, K.; Sakai, T.; Fukui, K.
    Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain (2009), J. Neural Transm., 116, 1335-1347.
    View publication on PubMed
Search for more literature for 1.4.3.3

Application

Application Comment Organism
drug development the enzyme is a potential therapeutic target for schizophrenia treatment Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Homo sapiens 5777
-
peroxisome
-
 Rattus norvegicus 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus O35078
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
flavoprotein
-
 Homo sapiens
flavoprotein
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain in choroid plexus epithelial cells and glial cells of rhombencephalon. Higher level of DAO expression is observed in schizophrenic choroid plexus epithelial cells than that in non-schizophrenic cases Homo sapiens
-
brain in choroid plexus epithelial cells, glial cells of pons, medulla oblongata, and especially in Bergmann glia of cerebellum Rattus norvegicus
-
cerebellum Bermann glia Rattus norvegicus
-
additional information in situ hybridization and immunohistochemic determination Homo sapiens
-
additional information in situ hybridization and immunohistochemic determination Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information D-amino acid oxidase is a flavoenzyme that catalyzes the oxidation of D-amino acids to the corresponding imino acids and hydrogen peroxide Homo sapiens ?
-
 ?
additional information D-amino acid oxidase is a flavoenzyme that catalyzes the oxidation of D-amino acids to the corresponding imino acids and hydrogen peroxide Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
DAO
-
 Homo sapiens
DAO
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
flavin flavoenzyme Homo sapiens
flavin flavoenzyme Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens higher level of DAO expression is observed in schizophrenic choroid plexus epithelial cells than that in non-schizophrenic cases up

General Information

General Information Comment Organism
malfunction an increase in DAO expression in parts of the brain is involved in aberrant D-amino acid metabolism Homo sapiens
physiological function DAO may regulate D-amino acid concentration by modulating the cerebrospinal fluid Homo sapiens