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Literature summary for 1.4.3.3 extracted from

  • Nguyen, L.P.; Hsu, E.L.; Chowdhury, G.; Dostalek, M.; Guengerich, F.P.; Bradfield, C.A.
    D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan (2009), Chem. Res. Toxicol., 22, 1897-1904.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of recombinant enzyme, using the CYP1A1 promoter, in murine hepatoma Hepa1c1c7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
beta-naphthoflavone
-
Homo sapiens
beta-naphthoflavone
-
Sus scrofa
Sodium benzoate inhibits the enzyme activity by by impeding the interaction of the enzyme with the flavin prosthetic group Homo sapiens
Sodium benzoate inhibits the enzyme activity by impeding the interaction of the enzyme with the flavin prosthetic group Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-tryptophan + H2O + O2 Homo sapiens DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid indole-3-pyruvic acid + NH3 + H2O2
-
?
D-tryptophan + H2O + O2 Sus scrofa DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid indole-3-pyruvic acid + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa P00371
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Sus scrofa
-
hepatoma cell line 101L cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-tryptophan + H2O + O2
-
Homo sapiens indole-3-pyruvic acid + NH3 + H2O2
-
?
D-tryptophan + H2O + O2
-
Sus scrofa indole-3-pyruvic acid + NH3 + H2O2
-
?
D-tryptophan + H2O + O2 DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid Homo sapiens indole-3-pyruvic acid + NH3 + H2O2
-
?
D-tryptophan + H2O + O2 DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid Sus scrofa indole-3-pyruvic acid + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
DAAO
-
Homo sapiens
DAAO
-
Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens
7.4
-
assay at Sus scrofa

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
FAD
-
Sus scrofa

General Information

General Information Comment Organism
physiological function the enzymatic function of DAAO is required for AHR activation by D-Trp and D-Tyr. DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid, followed by nonenzymatic oxidation and condensation of indole-3-pyruvic acid is a critical step in the generation of receptor agonists by DAAO and aspartate aminotransferase, AST. Products of this process include the two agonists, 1,3-di(1H-indol-3-yl)propan-2-one and 1-(1H-indol-3-yl)-3-(3H-indol- 3-ylidene) propan-2-one, overview Homo sapiens
physiological function the enzymatic function of DAAO is required for AHR activation by D-Trp and D-Tyr. DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid, followed by nonenzymatic oxidation and condensation of indole-3-pyruvic acid is a critical step in the generation of receptor agonists by DAAO and aspartate aminotransferase, AST. Products of this process include the two agonists, 1,3-di(1H-indol-3-yl)propan-2-one and 1-(1H-indol-3-yl)-3-(3H-indol- 3-ylidene) propan-2-one, overview Sus scrofa