Cloned (Comment) | Organism |
---|---|
expression of recombinant enzyme, using the CYP1A1 promoter, in murine hepatoma Hepa1c1c7 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-naphthoflavone | - |
Homo sapiens | |
beta-naphthoflavone | - |
Sus scrofa | |
Sodium benzoate | inhibits the enzyme activity by by impeding the interaction of the enzyme with the flavin prosthetic group | Homo sapiens | |
Sodium benzoate | inhibits the enzyme activity by impeding the interaction of the enzyme with the flavin prosthetic group | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + H2O + O2 | Homo sapiens | DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid | indole-3-pyruvic acid + NH3 + H2O2 | - |
? | |
D-tryptophan + H2O + O2 | Sus scrofa | DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid | indole-3-pyruvic acid + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Sus scrofa | P00371 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Sus scrofa | - |
hepatoma cell line | 101L cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + H2O + O2 | - |
Homo sapiens | indole-3-pyruvic acid + NH3 + H2O2 | - |
? | |
D-tryptophan + H2O + O2 | - |
Sus scrofa | indole-3-pyruvic acid + NH3 + H2O2 | - |
? | |
D-tryptophan + H2O + O2 | DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid | Homo sapiens | indole-3-pyruvic acid + NH3 + H2O2 | - |
? | |
D-tryptophan + H2O + O2 | DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid | Sus scrofa | indole-3-pyruvic acid + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DAAO | - |
Homo sapiens |
DAAO | - |
Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
7.4 | - |
assay at | Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
FAD | - |
Sus scrofa |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzymatic function of DAAO is required for AHR activation by D-Trp and D-Tyr. DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid, followed by nonenzymatic oxidation and condensation of indole-3-pyruvic acid is a critical step in the generation of receptor agonists by DAAO and aspartate aminotransferase, AST. Products of this process include the two agonists, 1,3-di(1H-indol-3-yl)propan-2-one and 1-(1H-indol-3-yl)-3-(3H-indol- 3-ylidene) propan-2-one, overview | Homo sapiens |
physiological function | the enzymatic function of DAAO is required for AHR activation by D-Trp and D-Tyr. DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid, followed by nonenzymatic oxidation and condensation of indole-3-pyruvic acid is a critical step in the generation of receptor agonists by DAAO and aspartate aminotransferase, AST. Products of this process include the two agonists, 1,3-di(1H-indol-3-yl)propan-2-one and 1-(1H-indol-3-yl)-3-(3H-indol- 3-ylidene) propan-2-one, overview | Sus scrofa |