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Literature summary for 1.4.3.3 extracted from

  • Hashimoto, K.; Fujita, Y.; Horio, M.; Kunitachi, S.; Iyo, M.; Ferraris, D.; Tsukamoto, T.
    Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine (2009), Biol. Psychiatry, 65, 1103-1106.
    View publication on PubMed
Search for more literature for 1.4.3.3

Application

Application Comment Organism
pharmacology co-administration of the enzyme inhibitor 5-chloro-benzo[d]isoxazol-3-ol significantly enhances the efficacy of D-serine in attenuating prepulse inhibition deficits by administration of dizocilpine, an NMDA receptor antagonist. Therefore, co-administration of D-serine and a DAAO inhibitor has therapeutic potential for the treatment of schizophrenia Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-chloro-benzo[d]isoxazol-3-ol
-
 Homo sapiens
5-chloro-benzo[d]isoxazol-3-ol
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-serine + H2O + O2 Homo sapiens D-serine, an endogenous agonist of the N-methyl-D-aspartate, NMDA, receptors, is effective in the treatment of schizophrenia. However, orally administered D-serine is metabolized substantially by D-amino acid oxidase diminishing its oral bioavailability 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
D-serine + H2O + O2 Mus musculus
-
 ? + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 Male Slc:ddy mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain frontal cortex Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-serine + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
D-serine + H2O + O2 D-serine, an endogenous agonist of the N-methyl-D-aspartate, NMDA, receptors, is effective in the treatment of schizophrenia. However, orally administered D-serine is metabolized substantially by D-amino acid oxidase diminishing its oral bioavailability Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
D-serine + H2O + O2
-
 Mus musculus ? + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
DAAO
-
 Mus musculus
DAAO
-
 Homo sapiens