Application | Comment | Organism |
---|---|---|
pharmacology | co-administration of the enzyme inhibitor 5-chloro-benzo[d]isoxazol-3-ol significantly enhances the efficacy of D-serine in attenuating prepulse inhibition deficits by administration of dizocilpine, an NMDA receptor antagonist. Therefore, co-administration of D-serine and a DAAO inhibitor has therapeutic potential for the treatment of schizophrenia | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-chloro-benzo[d]isoxazol-3-ol | - |
Homo sapiens | |
5-chloro-benzo[d]isoxazol-3-ol | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-serine + H2O + O2 | Homo sapiens | D-serine, an endogenous agonist of the N-methyl-D-aspartate, NMDA, receptors, is effective in the treatment of schizophrenia. However, orally administered D-serine is metabolized substantially by D-amino acid oxidase diminishing its oral bioavailability | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | Mus musculus | - |
? + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
Male Slc:ddy mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | frontal cortex | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-serine + H2O + O2 | - |
Homo sapiens | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | D-serine, an endogenous agonist of the N-methyl-D-aspartate, NMDA, receptors, is effective in the treatment of schizophrenia. However, orally administered D-serine is metabolized substantially by D-amino acid oxidase diminishing its oral bioavailability | Homo sapiens | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | - |
Mus musculus | ? + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DAAO | - |
Mus musculus |
DAAO | - |
Homo sapiens |