Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.3.3 extracted from

  • Ferraris, D.; Duvall, B.; Ko, Y.S.; Thomas, A.G.; Rojas, C.; Majer, P.; Hashimoto, K.; Tsukamoto, T.
    Synthesis and biological evaluation of D-amino acid oxidase inhibitors (2008), J. Med. Chem., 51, 3357-3359.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-(trifluoromethyl)-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
4-fluoro-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
5-bromo-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
5-iodo-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
5-nitro-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
6-(trifluoromethyl)-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
6-chlorobenzo[d]isoxazol-3-ol potent, competitive inhibitor Rattus norvegicus
6-ethoxy-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
6-fluoro-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
6-methoxy-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
6-methyl-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
6-nitro-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
7-fluoro-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
7-fluoro-6-(trifluoromethyl)-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
7-methyl-1,2-benzisoxazol-3-ol
-
Rattus norvegicus
benzo[d]isoxazol-3-ol
-
Rattus norvegicus
additional information negligible DAAO inhibition with muscimol, (S)-AMPA, 6-chloro-3-methoxybenzo[d]isoxazole, and 4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-serine + H2O + O2
-
Rattus norvegicus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
D-amino acid oxidase
-
Rattus norvegicus
DAAO
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000188
-
-
Rattus norvegicus 6-chlorobenzo[d]isoxazol-3-ol
0.000269
-
-
Rattus norvegicus 6-methyl-1,2-benzisoxazol-3-ol
0.000444
-
-
Rattus norvegicus 6-fluoro-1,2-benzisoxazol-3-ol
0.000599
-
-
Rattus norvegicus 5-bromo-1,2-benzisoxazol-3-ol
0.000722
-
-
Rattus norvegicus 6-nitro-1,2-benzisoxazol-3-ol
0.00151
-
-
Rattus norvegicus 5-iodo-1,2-benzisoxazol-3-ol
0.00188
-
-
Rattus norvegicus benzo[d]isoxazol-3-ol
0.00257
-
-
Rattus norvegicus 6-methoxy-1,2-benzisoxazol-3-ol
0.00295
-
-
Rattus norvegicus 5-nitro-1,2-benzisoxazol-3-ol
0.005
-
-
Rattus norvegicus 6-(trifluoromethyl)-1,2-benzisoxazol-3-ol
0.00782
-
-
Rattus norvegicus 4-fluoro-1,2-benzisoxazol-3-ol
0.023
-
-
Rattus norvegicus 7-fluoro-1,2-benzisoxazol-3-ol
0.1
-
IC50 above 0.1 mM Rattus norvegicus 4-(trifluoromethyl)-1,2-benzisoxazol-3-ol
0.1
-
IC50 above 0.1 mM Rattus norvegicus 6-ethoxy-1,2-benzisoxazol-3-ol
0.1
-
IC50 above 0.1 mM Rattus norvegicus 7-methyl-1,2-benzisoxazol-3-ol
0.1
-
IC50 above 0.1 mM Rattus norvegicus 7-fluoro-6-(trifluoromethyl)-1,2-benzisoxazol-3-ol