Literature summary for 1.4.3.3 extracted from

Hashimoto, A.; Yoshikawa, M.; Andoh, H.; Yano, H.; Matsumoto, H.; Kawaguchi, M.; Oka, T.; Kobayashi, H.
Effects of MK-801 on the expression of serine racemase and D-amino acid oxidase mRNAs and on the D-serine levels in rat brain (2007), Eur. J. Pharmacol., 555, 17-22.

Search for more literature for 1.4.3.3

Activating Compound

Activating Compound	Comment	Organism	Structure
(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine	MK-801, a dose-dependent elevation in the expression of DAO mRNA is observed in most brain areas 4 h after the administration (1.6 mg/kg)	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine	MK-801, a drastic decline in the expression of DAO mRNA is observed in most brain areas 1 h after the MK-801 administration (1.6 mg/kg)	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-serine + H2O + O2	-	Rattus norvegicus	2-oxo-3-hydroxypropionic acid + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
D-amino acid oxidase	-	Rattus norvegicus
DAO	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)