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Literature summary for 1.4.3.21 extracted from

  • Martelius, T.; Salmi, M.; Krogerus, L.; Loginov, R.; Schoultz, M.; Karikoski, M.; Miiluniemi, M.; Soots, A.; Hoeckerstedt, K.; Jalkanen, S.; Lautenschlager, I.
    Inhibition of semicarbazide-sensitive amine oxidases decreases lymphocyte infiltration in the early phases of rat liver allograft rejection (2009), Int. J. Immunopathol. Pharmacol., 21, 911-920.
    View publication on PubMed
Search for more literature for 1.4.3.21

Inhibitors

Inhibitors Comment Organism Structure
Semicarbazide
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Rattus norvegicus
-
-
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ required Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium
-
 Rattus norvegicus
-
liver luminal expression, immunohistochemic analysis, overview Rattus norvegicus
-
serum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzylamine + H2O + O2
-
 Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Rattus norvegicus

Synonyms

Synonyms Comment Organism
semicarbazide-sensitive amine oxidase
-
 Rattus norvegicus
SSAO
-
 Rattus norvegicus
VAP-1
-
 Rattus norvegicus
vascular adhesion protein 1
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function VAP-1 mediates lymphocyte adhesion to endothelia at sites of inflammation in vitro and in vivo. Inhibition of the SSAO activity of the enzyme by semicarbazid significantly decreases inflammatory cell infiltration in liver allografts, but does not influence the luminal expression of VAP-1 in the liver allografts Rattus norvegicus