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Literature summary for 1.4.3.2 extracted from

  • Costa Torres, A.F.; Dantas, R.T.; Toyama, M.H.; Diz Filho, E.; Zara, F.J.; Rodrigues de Queiroz, M.G.; Pinto Nogueira, N.A.; Rosa de Oliveira, M.; de Oliveira Toyama, D.; Monteiro, H.S.; Martins, A.M.
    Antibacterial and antiparasitic effects of Bothrops marajoensis venom and its fractions: phospholipase A2 and L-amino acid oxidase (2010), Toxicon, 55, 795-804.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Bothrops marajoensis
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
x * 72000, SDS-PAGE Bothrops marajoensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-leucine + H2O + O2 Bothrops marajoensis
-
2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
additional information Bothrops marajoensis the L-amino acid oxidase from Bothrops marajoensis is able to inhibit the growth of several microorganisms, including Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa,and Leishmania sp.. The enzyme inhibits the growth of promastigote forms of Leishmania amazonensis and Leishmania chagasi with IC50 values of 2.55 mg/mL and 2.86 mg/mL, respectively ?
-
?

Organism

Organism UniProt Comment Textmining
Bothrops marajoensis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme to high molecular homogeneity by ion exchange chromatography and reverse phase chromatography, followed by anion exchange chromatgography, ultrafiltration, and gel filtration Bothrops marajoensis

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Bothrops marajoensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-leucine + H2O + O2
-
Bothrops marajoensis 2-oxo-4-methylvaleric acid + NH3 + H2O2
-
?
additional information the L-amino acid oxidase from Bothrops marajoensis is able to inhibit the growth of several microorganisms, including Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa,and Leishmania sp.. The enzyme inhibits the growth of promastigote forms of Leishmania amazonensis and Leishmania chagasi with IC50 values of 2.55 mg/mL and 2.86 mg/mL, respectively Bothrops marajoensis ?
-
?
additional information LAAO catalyzes the stereospecific oxidative deamination of an L-amino acid substrate, releasing the corresponding 2-oxo acid and resulting in the production of hydrogen peroxide and ammonia Bothrops marajoensis ?
-
?

Subunits

Subunits Comment Organism
? x * 72000, SDS-PAGE Bothrops marajoensis

Synonyms

Synonyms Comment Organism
L-amino acid: O2 oxidoreductase
-
Bothrops marajoensis
LAAO
-
Bothrops marajoensis

Cofactor

Cofactor Comment Organism Structure
FAD
-
Bothrops marajoensis