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Literature summary for 1.4.3.13 extracted from

  • Papachroni, K.K.; Piperi, C.; Levidou, G.; Korkolopoulou, P.; Pawelczyk, L.; Diamanti-Kandarakis, E.; Papavassiliou, A.G.
    Lysyl oxidase interacts with AGEs signaling to modulate collagen synthesis in polycystic ovarian tissue (2010), J. Cell. Mol. Med., 14, 2460-2469.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
ovary stromal tissue and ovarian follicle, polycystic ovarian tissue Homo sapiens
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Synonyms

Synonyms Comment Organism
LOX
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 Homo sapiens
lysyl oxidase
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated in polycystic ovarian tissue by LOX promoter binding of transcription factors, e.g. NF-kappaB and activator protein-1, induced in advanced glycation end product, AEG, signaling, overview up

General Information

General Information Comment Organism
malfunction excess collagen deposition in ovarian stroma in polycystic ovary syndrome involves increased enzyme activity due to stimulation by advenced glycation end products Homo sapiens
physiological function the enzyme is involved n collagen synthesis. It catalyzes the collagen and elastin cross-linking and plays an essential role in coordinating the control of ovarian extracellular matrix during ovarian follicle development, overview Homo sapiens