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Literature summary for 1.4.3.13 extracted from

  • Onoda, M.; Yoshimura, K.; Aoki, H.; Ikeda, Y.; Morikage, N.; Furutani, A.; Matsuzaki, M.; Hamano, K.
    Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm (2009), Atherosclerosis, 208, 366-369.
    View publication on PubMed
Search for more literature for 1.4.3.13

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
beta-aminopropionitrile reduces LOX activity and significantly increases MCP-1 secretion in vascular smooth uscle cells Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ copper-containing enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus lysyl oxidase is a copper-dependent amine oxidase that catalyzes the crosslinking of collagens and elastin, and is thus critical for the stability of the extracellular matrix ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
aorta
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 Rattus norvegicus
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vascular smooth muscle cell
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information lysyl oxidase is a copper-dependent amine oxidase that catalyzes the crosslinking of collagens and elastin, and is thus critical for the stability of the extracellular matrix Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
LOX
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 Rattus norvegicus
lysyl oxidase
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function lysyl oxidase is a copper-dependent amine oxidase that catalyzes the crosslinking of collagens and elastin, and is thus critical for the stability of the extracellular matrix. LOX mediates suppression of MCP-1, one of the highly upregulated chemokines, and subsequent inflammatory responses, overview Rattus norvegicus