Literature summary for 1.4.3.13 extracted from

Hewitt, A.W.; Sharma, S.; Burdon, K.P.; Wang, J.J.; Baird, P.N.; Dimasi, D.P.; Mackey, D.A.; Mitchell, P.; Craig, J.E.
Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people (2008), Hum. Mol. Genet., 17, 710-716.

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Protein Variants

Protein Variants	Comment	Organism
G153D	the mutation is strongly associated with pseudoexfoliation syndrome	Homo sapiens
R141L	the mutation is strongly associated with pseudoexfoliation syndrome	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
42000	-	mature enzyme, SDS-PAGE	Homo sapiens
80000	-	polymerized enzyme, SDS-PAGE	Homo sapiens
130000	-	polymerized LOXL1 precursor protein, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ciliary body	mature form of LOXL1 and polymerized LOXL1protein forms	Homo sapiens	-
cornea	polymerized LOXL1protein forms	Homo sapiens	-
HEK-293A cell	-	Homo sapiens	-
HLEC-SRA 01/04 cell	-	Homo sapiens	-
iris	mature form of LOXL1 and polymerized LOXL1protein forms	Homo sapiens	-
lens capsule	polymerized LOXL1protein forms	Homo sapiens	-
additional information	no LOXL1 expression in retina	Homo sapiens	-
optic nerve	polymerized LOXL1protein forms	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
peptidyl-L-lysyl-peptide + O2 + H2O	-	Homo sapiens	peptidyl-allysyl-peptide + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
LOXL1	-	Homo sapiens
lysyl oxidase-like 1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
lysyl-tyrosyl-quinone	-	Homo sapiens

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Release 2023.1 (January 2023)