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Literature summary for 1.4.1.4 extracted from

  • Pagliarulo, C.; Salvatore, P.; de Vitis, L.R.; Colicchio, R.; Monaco, C.; Tredici, M.; Tala, A.; Bardaro, M.; Lavitola, A.; Bruni, C.B.; Alifano, P.
    Regulation and differential expression of gdhA encoding NADP-specific glutamate dehydrogenase in Neisseria meningitidis clinical isolates (2004), Mol. Microbiol., 51, 1757-1772.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Neisseria meningitidis the enzyme is encoded by gdhA. In strains expressing high levels of gdhA mRNA, two promoters, gdhA P1 and gdhA P2, initiate transcription of gdhA. In strains expressing low mRNA levels, gdhA P2 is not active because of weak expression of GdhR, an associated regulatory gene. 2-Oxoglutarate inhibits binding of GdhR to gdhA P2 ?
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Organism

Organism UniProt Comment Textmining
Neisseria meningitidis
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is encoded by gdhA. In strains expressing high levels of gdhA mRNA, two promoters, gdhA P1 and gdhA P2, initiate transcription of gdhA. In strains expressing low mRNA levels, gdhA P2 is not active because of weak expression of GdhR, an associated regulatory gene. 2-Oxoglutarate inhibits binding of GdhR to gdhA P2 Neisseria meningitidis ?
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?

Synonyms

Synonyms Comment Organism
NADP-GDH
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Neisseria meningitidis
NADP-specific L-glutamate dehydrogenase
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Neisseria meningitidis

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Neisseria meningitidis