Literature summary for 1.4.1.3 extracted from

Choi, M.M.; Kim, E.A.; Choi, S.Y.; Kim, T.U.; Cho, S.W.; Yang, S.J.
Inhibitory properties of nerve-specific human glutamate dehydrogenase isozyme by chloroquine (2007), J. Biochem. Mol. Biol., 40, 1077-1082.

Search for more literature for 1.4.1.3

Activating Compound

Activating Compound	Comment	Organism	Structure
ADP	-	Homo sapiens
GTP	-	Homo sapiens
L-leucine	-	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Chloroquine	potent inhibitor of isozymes GDH1 and GDH2 at a dose-dependent manner, the inhibitory effect of chloroquine on GDH2 is abolished by the presence of ADP and L-leucine, whereas GTP does not change the sensitivity to chloroquine inhibition, shows a non-competitive inhibition against 2-oxoglutarate and an uncompetitive inhibition against NADH	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
nerve	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamate + H2O + NAD(P)+	-	Homo sapiens	2-oxoglutarate + NH3 + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
GDH1	housekeeping isozyme	Homo sapiens
GDH2	nerve-specific isozyme	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD(P)+	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.05	-	GDH1	Homo sapiens	Chloroquine
0.14	-	GDH2	Homo sapiens	Chloroquine

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Release 2023.1 (January 2023)