Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP | 1 mM, pH 8.0, 3fold activation of wild-type enzyme, no significant actication of Tyr187 mutant enzymes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Y187E | KM-values for NADH and 2-oxoglutareta are similar to wild-type values, about 4fold decrease of Vmax | Homo sapiens |
Y187G | KM-values for NADH and 2-oxoglutareta are similar to wild-type values, about 4fold decrease of Vmax, no significant actication by ADP | Homo sapiens |
Y187M | KM-values for NADH and 2-oxoglutareta are similar to wild-type values, about 4fold decrease of Vmax, no significant actication by ADP | Homo sapiens |
Y187S | KM-values for NADH and 2-oxoglutareta are similar to wild-type values, about 4fold decrease of Vmax, no significant actication by ADP | Homo sapiens |
Y197R | KM-values for NADH and 2-oxoglutareta are similar to wild-type values, about 4fold decrease of Vmax, no significant actication by ADP | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.08 | - |
NADH | pH 8.0, 25°C, wild-type enzyme | Homo sapiens | |
0.082 | - |
NADH | pH 8.0, 25°C, mutant enzyme Y187E | Homo sapiens | |
0.082 | - |
NADH | pH 8.0, 25°C, mutant enzyme Y187R | Homo sapiens | |
0.084 | - |
NADH | pH 8.0, 25°C, mutant enzyme Y187M | Homo sapiens | |
0.085 | - |
NADH | pH 8.0, 25°C, mutant enzyme Y187G | Homo sapiens | |
0.088 | - |
NADH | pH 8.0, 25°C, mutant enzyme Y187S | Homo sapiens | |
1.25 | - |
2-oxoglutarate | pH 8.0, 25°C, wild-type enzyme | Homo sapiens | |
1.29 | - |
2-oxoglutarate | pH 8.0, 25°C, mutant enzyme Y187E | Homo sapiens | |
1.31 | - |
2-oxoglutarate | pH 8.0, 25°C, mutant enzyme Y187M | Homo sapiens | |
1.44 | - |
2-oxoglutarate | pH 8.0, 25°C, mutant enzyme Y187R | Homo sapiens | |
1.45 | - |
2-oxoglutarate | pH 8.0, 25°C, mutant enzyme Y187G | Homo sapiens | |
1.46 | - |
2-oxoglutarate | pH 8.0, 25°C, mutant enzyme Y187S | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + NADH + NH3 | - |
Homo sapiens | L-glutamate + NAD+ + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens |