Any feedback?
Literature summary for 1.4.1.3 extracted from
- Kinetic mechanism of glutamate dehydrogenase (1980), Biochemistry, 19, 2321-2328.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-oxobutyrate | - |
Bos taurus |  |
| 2-oxoglutarate | - |
Bos taurus | |
| 2-oxovalerate | - |
Bos taurus | |
| L-glutamate | - |
Bos taurus | |
| NADP+ | - |
Bos taurus | |
| NADPH | - |
Bos taurus | |
| NH4+ | - |
Bos taurus | |
| norvaline | - |
Bos taurus | |
| oxalylglycine | competitive vs. 2-oxoglutarate, uncompetitive vs. NADPH, noncompetitive vs. NH4+ | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.022 | - |
NADPH | - |
Bos taurus | |
| 0.028 | - |
NADP+ | cosubstrate glutamate | Bos taurus | |
| 0.31 | - |
NADP+ | cosubstrate norvaline | Bos taurus | |
| 0.74 | - |
L-glutamate | - |
Bos taurus | |
| 2.4 | - |
2-oxoglutarate | - |
Bos taurus | |
| 6.5 | - |
NH4+ | - |
Bos taurus | |
| 49 | - |
norvaline | - |
Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+ | mechanism | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate + H2O + NAD(P)+ | - |
Bos taurus | 2-oxoglutarate + NH3 + NAD(P)H | - |
r | |
| norvaline + H2O + NAD(P)+ | - |
Bos taurus | 2-oxopentanoate + NH3 + NAD(P)H | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.028 | - |
NADPH | - |
Bos taurus | |
| 0.24 | - |
NADP+ | - |
Bos taurus | |
| 0.315 | - |
2-oxoglutarate | - |
Bos taurus | |
| 0.36 | - |
oxalylglycine | vs. 2-oxoglutarate | Bos taurus | |
| 0.54 | - |
oxalylglycine | vs. NADPH | Bos taurus | |
| 0.9 | - |
oxalylglycine | vs. NH4+ | Bos taurus | |
| 2.9 | - |
NH4+ | - |
Bos taurus | |
| 6.3 | - |
L-glutamate | - |
Bos taurus | |
| 24.4 | - |
2-oxovalerate | - |
Bos taurus | |
| 31 | - |
2-oxobutyrate | - |
Bos taurus | |
| 60 | - |
2-oxoglutarate | substrate inhibition vs. NADPH | Bos taurus | |
| 70 | - |
2-oxoglutarate | substrate inhibition vs. NH4+ | Bos taurus | |
| 78 | - |
norvaline | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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