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Literature summary for 1.4.1.2 extracted from
- Kinetic properties and the mechanism of activation of NAD-dependent glutamate dehydrogenase from Dictyostelium discoideum (1996), Biochem. Mol. Biol. Int., 38, 729-738.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| AMP | stimulation | Dictyostelium discoideum |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.037 | - |
NADH | non-activated NAD-GDH | Dictyostelium discoideum | |
| 0.09 | - |
NADH | activated NAD-GDH | Dictyostelium discoideum | |
| 0.75 | - |
2-oxoglutarate | activated NAD-GDH | Dictyostelium discoideum | |
| 1.9 | - |
2-oxoglutarate | non-activated NAD-GDH | Dictyostelium discoideum | |
| 22.8 | - |
NH4+ | non-activated NAD-GDH | Dictyostelium discoideum | |
| 25.6 | - |
NH4+ | activated NAD-GDH | Dictyostelium discoideum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dictyostelium discoideum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| activated and non-activated form | Dictyostelium discoideum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoglutarate + NH4+ + NADPH | - |
Dictyostelium discoideum | L-glutamate + NADP+ | - |
? | |
| L-glutamate + H2O + NAD+ | - |
Dictyostelium discoideum | 2-oxoglutarate + NH3 + NADH + H+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Dictyostelium discoideum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Dictyostelium discoideum | |
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