Literature summary for 1.4.1.16 extracted from

Kind, S.; Jeong, W.K.; Schroeder, H.; Wittmann, C.
Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane (2010), Metab. Eng., 12, 341-351.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene ddh, overexpression in Corynebacterium glutamicum, co-expression with other enzyme of the metabolic pathway for cadaverine, i.e. N-acetyl-diaminopentane, production, overview	Corynebacterium glutamicum

Protein Variants

Protein Variants	Comment	Organism
additional information	systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane. Superior strains with desirable properties such as (i) the release from unwanted feedback regulation at the level of aspartokinase and pyruvate carboxylase by introducing the point mutations lysC311 and pycA458, (ii) an optimized supply of the key precursor oxaloacetate by amplifying the anaplerotic enzyme, pyruvate carboxylase, and deleting phosphoenolpyruvate carboxykinase which otherwise removes oxaloacetate, (iii) enhanced biosynthetic flux via combined amplification of aspartokinase, dihydrodipicolinate reductase, diaminopimelate dehydrogenase and diaminopimelate decarboxylase, and (iv) attenuated flux into the threonine pathway competing with production by the leaky mutation hom59 in the homoserine dehydrogenasegene	Corynebacterium glutamicum

Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	-	gene ddh	-

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Release 2023.1 (January 2023)