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Literature summary for 1.4.1.16 extracted from

  • Abbott, S.D.; Lane-Bell, P.; Sidhu, K.P.S.; Vederas, J.C.
    Synthesis and testing of heterocyclic analogues of diaminopimelic acid (DAP) as inhibitors of DAP dehydrogenase and DAP epimerase (1994), J. Am. Chem. Soc., 116, 6513-6520.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
(2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid competitive inhibition Lysinibacillus sphaericus

Organism

Organism UniProt Comment Textmining
Lysinibacillus sphaericus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H
-
Lysinibacillus sphaericus meso-2,6-diaminoheptanedioate + H2O + NAD(P)+
-
r

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Lysinibacillus sphaericus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0042
-
(2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid competitive inhibition of L-2-amino-6-oxoheptanedioate Lysinibacillus sphaericus
0.023
-
(2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid noncompetitive inhibition of meso-diaminopimelate Lysinibacillus sphaericus