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Literature summary for 1.3.99.5 extracted from
- In vitro inhibition of testicular delta 5-3 beta-hydroxysteroid dehydrogenase and prostatic 5 alpha-reductase activities in rats and humans by strogen forte extract (1996), Int. Urol. Nephrol., 28, 337-348.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibitor Strogen forte extract can be used for treatment of benign prostatic hyperplasia | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Strogen forte | standardized extract of the plant Sabalis serrulata, 0.245 mg/ml result in 50% enzyme inhibition | Homo sapiens | |
| Strogen forte | standardized extract of the plant Sabalis serrulata, 0.385 mg/ml result in 50% enzyme inhibition | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| prostate gland | - |
Homo sapiens | - |
| prostate gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| testosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADP+ | - |
? |  |
| testosterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-dihydrotestosterone + NADP+ | - |
? | |
| testosterone + NADPH + H+ | - |
Rattus norvegicus Wistar | 5alpha-dihydrotestosterone + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5alpha-R | - |
Homo sapiens |
| 5alpha-R | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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