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Literature summary for 1.3.99.5 extracted from

  • Cohen, R.E.; Wade, J.
    Testosterone selectively affects aromatase and 5alpha-reductase activities in the green anole lizard brain (2010), Gen. Comp. Endocrinol., 166, 128-133.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
testosterone 5alpha-reductase activity in males is increased by testosterone regardless of breeding season, thus, testosterone appears to regulate its own metabolism in male, but not female, anoles Anolis carolinensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-dihydrotestosterone + NADP+ Anolis carolinensis 5alpha-reductase converts testosterone to 5alpha-dihydrotestosterone testosterone + NADPH + H+
-
r
5alpha-pregn-3,20-dione + NADP+ Anolis carolinensis 5alpha-reductase also can act on progesterone, which is metabolized to an intermediate product that is then converted to allopregnanolone progesterone + NADPH + H+
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r

Organism

Organism UniProt Comment Textmining
Anolis carolinensis
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain enzyme activity in both sexes Anolis carolinensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-dihydrotestosterone + NADP+
-
Anolis carolinensis testosterone + NADPH + H+
-
r
5alpha-dihydrotestosterone + NADP+ 5alpha-reductase converts testosterone to 5alpha-dihydrotestosterone Anolis carolinensis testosterone + NADPH + H+
-
r
5alpha-pregn-3,20-dione + NADP+
-
Anolis carolinensis progesterone + NADPH + H+
-
r
5alpha-pregn-3,20-dione + NADP+ 5alpha-reductase also can act on progesterone, which is metabolized to an intermediate product that is then converted to allopregnanolone Anolis carolinensis progesterone + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
5alpha-reductase
-
Anolis carolinensis

General Information

General Information Comment Organism
physiological function the type I enzyme is important for catabolism of excess steroids, while the type II enzyme has some role in male sexual behavior, whereas no evidence exists for it influencing female receptivity in this species. But 5alpha-reductase may play a role in regulating the effects of progesterone on female reproductive behavior. Females may have lower levels of type II than males Anolis carolinensis