Literature summary for 1.3.99.5 extracted from

Levy, H.R.; Talalay, P.
Bacterial oxidation of steroids. II. Studies on the enzymatic mechanism of ring A dehydrogenation (1959), J. Biol. Chem., 234, 2014-2021.

Search for more literature for 1.3.99.5

Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	1 mM, 29% inhibition	Comamonas testosteroni
1,4-androstadiene-3,17-dione	-	Comamonas testosteroni
2,2'-dipyridyl	1 mM, 22% inhibition	Comamonas testosteroni
8-hydroxyquinoline	1 mM, 10% inhibition	Comamonas testosteroni
CuSO4	1 mM, 95% inhibition	Comamonas testosteroni
EDTA	1 mM, 23% inhibition	Comamonas testosteroni
estrone	-	Comamonas testosteroni
HgCl2	1 mM, complete inhibition	Comamonas testosteroni
iodoacetamide	1 mM, 11% inhibition	Comamonas testosteroni
iodoacetate	1 mM, 8% inhibition	Comamonas testosteroni
KCN	1 mM, 24% inhibition	Comamonas testosteroni
MnSO4	1 mM, 42% inhibition	Comamonas testosteroni
NaN3	1 mM, 26% inhibition	Comamonas testosteroni
o-Iodosobenzoate	1 mM, complete inhibition	Comamonas testosteroni
p-chloromercuribenzoate	1 mM, 43% inhibition	Comamonas testosteroni
ZnSO4	1 mM, 53% inhibition	Comamonas testosteroni

Organism

Organism	UniProt	Comment	Textmining
Comamonas testosteroni	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-androstene-3,17-dione + phenazine methosulfate	-	Comamonas testosteroni	1,4-androstadiene-3,17-dione + reduced phenazine methosulfate	-	ir
1-estrene-3,17-dione + phenazine methosulfate	-	Comamonas testosteroni	1,4-estradiene-3,17-dione + reduced phenazine methosulfate	-	ir

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
9.5	-	-	Comamonas testosteroni

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Release 2023.1 (January 2023)