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Literature summary for 1.3.98.1 extracted from

  • Pawlik, A.; Herczynska, M.; Kurzawski, M.; Safranow, K.; Dziedziejko, V.; Drozdzik, M.
    The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide (2009), Pharmacogenomics, 10, 303-309.
    View publication on PubMed

Application

Application Comment Organism
medicine in patients with rheumatoid arthritis treated with leflunomide, the frequency of remission is increased in patients carrying the C allele of single nucleotide polymorphism 19C>A compared with patients carrying the A allele Homo sapiens

Protein Variants

Protein Variants Comment Organism
Q7L single nucleotide polymorphism due to missense polymorphism 19C>A, leading to amino acid substitution in the cationic N-terminal region of the polypeptide Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
patients with rheumatoid arthritis
-