Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.98.1 extracted from

  • Arakaki, T.L.; Buckner, F.S.; Gillespie, J.R.; Malmquist, N.A.; Phillips, M.A.; Kalyuzhniy, O.; Luft, J.R.; Detitta, G.T.; Verlinde, C.L.; Van Voorhis, W.C.; Hol, W.G.; Merritt, E.A.
    Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies (2008), Mol. Microbiol., 68, 37-50.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.98.1

Inhibitors

Inhibitors Comment Organism Structure
3,4-dihydroxybenzoate competitive inhibition at 1 mM Trypanosoma brucei
3,5-Dihydroxybenzoate non-competitive inhibition at 1 mM Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
 S-dihydroorotate
-
 Trypanosoma brucei
0.08
-
 fumarate
-
 Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information does not perform electron transfer to menaquinone, Q0, Q1, Q2, QD, O2, or to NAD+ Trypanosoma brucei ?
-
 ?
S-dihydroorotate + 2,6-dichlorophenolindophenol
-
 Trypanosoma brucei orotate + reduced 2,6-dichlorophenolindophenol
-
 ?
S-dihydroorotate + fumarate 100% activity Trypanosoma brucei orotate + succinate
-
 ?
S-dihydroorotate + menadione 20% activity with menadione compared to fumarate Trypanosoma brucei orotate + menadiol
-
 ?

Synonyms

Synonyms Comment Organism
class 1A DHODH
-
 Trypanosoma brucei

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
8.5
-
 fumarate apparent value Trypanosoma brucei

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
 Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
FMN
-
 Trypanosoma brucei