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Literature summary for 1.3.8.7 extracted from

  • Gradinaru, R.; Schowen, R.; Ghisla, S.
    Solvent isotope effects in reactions of human medium-chain acyl-CoA dehydrogenase active site mutants (2007), Biochemistry, 46, 2497-2509.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E376G the rate of dehydrogenation is lowered by approximately 5 orders of magnitude Homo sapiens
E376Q the rate of dehydrogenation is lowered by 4-5 orders of magnitude Homo sapiens
E376Q/E99G the rate of dehydrogenation is lowered by 4-5 orders of magnitude Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + acceptor
-
Homo sapiens 2,3-dehydroacyl-CoA + reduced acceptor
-
?
octanoyl-CoA + acceptor
-
Homo sapiens 2-octenoyl-CoA + reduced acceptor
-
?

Synonyms

Synonyms Comment Organism
MCAD
-
Homo sapiens
medium-chain acyl-CoA dehydrogenase
-
Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
25
-
mutant enzyme E376Q is instable at 25°C Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens