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Literature summary for 1.3.8.7 extracted from
- The pimFABCDE operon from Rhodopseudomonas palustris mediates dicarboxylic acid degradation and participates in anaerobic benzoate degradation (2005), Microbiology, 151, 1963-1974.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | acyl-CoA dehydrogenase LipB is involved in the introduction of the unusual Dcis3 double bond into the acyl residue of friulimicin | Actinoplanes friuliensis |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cloned on plasmid pEHEX2 and heterologous expression in Streptomyces lividans T7 | Actinoplanes friuliensis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | lipB insertion mutant, zone of growth inhibition around mutant is only ca. 62% of the wild-type inhibition zone indicating a reduced friulimicin production or a modified, less biologically active friulimicin production | Actinoplanes friuliensis |
| additional information | mutant strain deleted in the pim gene cluster, grows at about half the rate of the wild-type parent when benzoate or pimelate is supplied as the sole carbon source, grows five times more slowly than the wild-type on the C14 dicarboxylic acid tetradecanedioate, but is unimpaired in growth on the C8-fatty acid caprylate | Rhodopseudomonas palustris |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Actinoplanes friuliensis | - |
- |
- |
| Rhodopseudomonas palustris | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Actinoplanes friuliensis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | beta-oxidation enzymes encoded by the pim gene cluster including acyl CoA dehydrogenase are active with medium-chain-length dicarboxylic acids | Rhodopseudomonas palustris | ? | - |
? |  |
| additional information | involved in the formation of unsaturated fatty acid | Actinoplanes friuliensis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acyl CoA dehydrogenase | - |
Rhodopseudomonas palustris |
| acyl-CoA dehydrogenase | - |
Actinoplanes friuliensis |
| LipB | - |
Actinoplanes friuliensis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Actinoplanes friuliensis | |
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Release 2023.1 (January 2023)
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