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Literature summary for 1.3.8.4 extracted from
- Role of isovaleryl-CoA dehydrogenase and short branched-chain acyl-CoA dehydrogenase in the metabolism of valproic acid: implications for the branched-chain amino acid oxidation pathway (2011), Drug Metab. Dispos., 39, 1155-1160.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| valproyl-CoA | competitive | Rattus norvegicus |  |
| valproyl-dephosphoCoA | competitive | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.125 | - |
isovaleryl-CoA | pH 8.0, 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isovaleryl-CoA + FAD | Rattus norvegicus | - |
3-methylcrotonyl-CoA + FADH2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P12007 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isovaleryl-CoA + FAD | - |
Rattus norvegicus | 3-methylcrotonyl-CoA + FADH2 | - |
? | |
| isovaleryl-CoA + FAD | with ferrocenium hexafluorophosphate as second electron acceptor | Rattus norvegicus | 3-methylcrotonyl-CoA + FADH2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IVD | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics, overview | Rattus norvegicus | |
| 0.074 | - |
valproyl-CoA | versus isovaleryl-CoA, pH 8.0, 37°C | Rattus norvegicus | |
| 0.17 | - |
valproyl-dephosphoCoA | versus isovaleryl-CoA, pH 8.0, 37°C | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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