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Literature summary for 1.3.8.1 extracted from

  • Skilling, H.; Coen, P.M.; Fairfull, L.; Ferrell, R.E.; Goodpaster, B.H.; Vockley, J.; Goetzman, E.S.
    Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice (2010), Biochem. Biophys. Res. Commun., 400, 318-322.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
butanoyl-CoA + acceptor Mus musculus
-
but-2-enoyl-CoA + reduced acceptor
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
BALB/cJ mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butanoyl-CoA + acceptor
-
Mus musculus but-2-enoyl-CoA + reduced acceptor
-
?

Synonyms

Synonyms Comment Organism
SCAD
-
Mus musculus
short-chain acyl-CoA dehydrogenase
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Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Mus musculus

General Information

General Information Comment Organism
additional information short-chain acyl-CoA dehydrogenase-deficient mice, SCAD-/- mice, have increased brown adipose tissue mass as well as modest cardiac hypertrophy. Uncoupling protein-1 is reduced by 70% in brown adipose tissue, not due to a change in mitochondrial number, nor to decreased signal transduction through protein kinase A, which is known to be a major regulator of uncoupling protein-1 expression, phenotype, overview. Reduced brown adipose tissue function is not the major factor causing cold sensitivity in acyl-CoA dehydrogenase knockout strains, but other mechanisms such as shivering capacity, cardiac function, and reduced hepatic glycogen stores are involved Mus musculus