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Literature summary for 1.3.8.1 extracted from
- Studies on the fatty acid oxidization system of animal tissues. IV. The prosthetic group of butyryl coenzyme A dehydrogenase (1954), J. Biol. Chem., 206, 13-26.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| CN- | activates the enzyme in reaction with ferricytochrome c or ferricyanide as electron acceptors, but not with flavin D or FAd | Sus scrofa |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-chloromercuribenzoate | 0.1 mM, 40% inhibition | Bos taurus | |
| 4-chloromercuribenzoate | inhibition is reversible by glutathione | Sus scrofa | |
| Hg2+ | - |
Sus scrofa | |
| additional information | no inhibition by CN- | Sus scrofa |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| copper | 2 mol copper /mol FAD, cupric ion can be removed by dialysis against cyanide, copper is not involved in redox reaction | Bos taurus | |
| Cu2+ | 10-12 copper ions per enzyme molecule, enzyme-bound copper. The Cu2+ does not play a role in the primary reduction of the flavin-bound enzyme | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 120000 | 220000 | gel filtration | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butanoyl-CoA + oxidized acceptor | Sus scrofa | - |
crotonyl-CoA + reduced acceptor | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butanoyl-CoA + oxidized acceptor | - |
Sus scrofa | crotonyl-CoA + reduced acceptor | - |
r | |
| additional information | no activity with octanoyl-CoA and acetyl-CoA | Sus scrofa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| butyryl CoA dehydrogenase | - |
Sus scrofa |
| butyryl coenzyme A dehydrogenase | - |
Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | 38 | assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | about 5 or 6 FAD molecules per enzyme molecule | Bos taurus | |
| FAD | enzyme-bound, flavin D | Sus scrofa | |
| ferricytochrome c | - |
Sus scrofa | |
| riboflavin | enzyme-bound | Sus scrofa | |
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Release 2023.1 (January 2023)
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