Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.8.1 extracted from

  • Finocchiaro, G.; Ito, M.; Tanaka, K.
    Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver (1987), J. Biol. Chem., 262, 7982-7989.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(methylenecyclopropyl)acetyl-CoA 0.01 mM, 81% inhibition, 0.001 mM, 49% inhibition Homo sapiens
iodoacetamide 2 mM, 63% inhibition Homo sapiens
N-ethylmaleimide 2 mM, 41% inhibition, 0.2 mM, 23% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0041
-
electron transfer flavoprotein
-
Homo sapiens
0.0129
-
butyryl-CoA
-
Homo sapiens
0.0333
-
pentanoyl-CoA
-
Homo sapiens
0.0339
-
hexanoyl-CoA
-
Homo sapiens
0.179
-
phenazine methosulfate
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41200
-
4 * 41200, SDS-PAGE Homo sapiens
168000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.4
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyryl-CoA + electron acceptor intermediate electron acceptors phenazine methosulfate or electron transfer flavoprotein Homo sapiens 2-butenoyl-CoA + reduced acceptor
-
?
butyryl-CoA + electron acceptor terminal electron acceptor 2,6-dichlorophenol-indophenol Homo sapiens 2-butenoyl-CoA + reduced acceptor
-
?
butyryl-CoA + electron acceptor intermediate electron acceptor phenazine methosulfate Homo sapiens 2-butenoyl-CoA + reduced acceptor
-
?
hexanoyl-CoA + electron transfer flavoprotein
-
Homo sapiens 2-hexenoyl-CoA + reduced acceptor
-
?
hexanoyl-CoA + phenazine methosulfate + dichloroindophenol
-
Homo sapiens 2-hexenoyl-CoA + reduced acceptor
-
?
pentanoyl-CoA + electron transfer flavoprotein
-
Homo sapiens 2-pentenoyl-CoA + reduced acceptor
-
?
pentanoyl-CoA + phenazine methosulfate pentanoyl-CoA i.e. valeryl-CoA Homo sapiens 2-pentenoyl-CoA + reduced acceptor
-
?
propionyl-CoA + electron transfer flavoprotein
-
Homo sapiens 2-propenoyl-CoA + reduced acceptor
-
?
propionyl-CoA + phenazine methosulfate
-
Homo sapiens 2-propenoyl-CoA + reduced acceptor
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 41200, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
16.5
-
hexanoyl-CoA
-
Homo sapiens
20.8
-
butyryl-CoA
-
Homo sapiens
40.7
-
valeryl-CoA
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9 less than 50% of maximal activity above and below Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD 1 mol per mol of subunit Homo sapiens