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Literature summary for 1.3.7.8 extracted from

  • Mobitz, H.; Friedrich, T.; Boll, M.
    Substrate binding and reduction of benzoyl-CoA reductase: evidence for nucleotide-dependent conformational changes (2004), Biochemistry, 43, 1376-1385.
    View publication on PubMed
Search for more literature for 1.3.7.8

Inhibitors

Inhibitors Comment Organism Structure
4-fluoro-benzoyl-CoA
-
 Thauera aromatica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information detailed kinetic analysis Thauera aromatica
0.019
-
 2-amino-benzoyl-CoA
-
 Thauera aromatica
0.037
-
 benzoyl-CoA
-
 Thauera aromatica
0.043
-
 3-fluoro-benzoyl-CoA
-
 Thauera aromatica
0.056
-
 2-hydroxy-benzoyl-CoA
-
 Thauera aromatica
0.066
-
 2-chloro-benzoyl-CoA
-
 Thauera aromatica
0.094
-
 thiophene-2-carbonyl-CoA
-
 Thauera aromatica
0.152
-
 2-fluoro-benzoyl-CoA
-
 Thauera aromatica
0.375
-
 pyridine-2-carbonyl-CoA
-
 Thauera aromatica
0.625
-
 pyridine-4-carbonyl-CoA
-
 Thauera aromatica
2.5
-
 furan-2-carbonyl-CoA
-
 Thauera aromatica

Organism

Organism UniProt Comment Textmining
Thauera aromatica
-
-
-

Reaction

Reaction Comment Organism Reaction ID
cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 ADP + 2 phosphate = benzoyl-CoA + reduced ferredoxin + 2 ATP + 2 H2O ATP-binding switch is rather fast, reverse switch back of MgADP-bound enzyme is considered rate-limiting, binding of nucleotides does not affect redox potential of 4Fe-4S clusters Thauera aromatica
a
cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 ADP + 2 phosphate = benzoyl-CoA + reduced ferredoxin + 2 ATP + 2 H2O Birch-like mechanism Thauera aromatica
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-benzoyl-CoA + reduced methyl viologen + ATP at 11% of the velocity of benzoyl-CoA Thauera aromatica 2-amino-cyclohexa-1,5-diene-1-carbonyl-CoA + methyl viologen + ADP + phosphate
-
 ?
2-chloro-benzoyl-CoA + reduced methyl viologen + ATP at 106% of the velocity of benzoyl-CoA Thauera aromatica 2-chloro-cyclohexa-1,5-diene-1-carbonyl-CoA + methyl viologen + ADP + phosphate
-
 ?
2-fluoro-benzoyl-CoA + reduced methyl viologen + ATP at 145% of the velocity of benzoyl-CoA Thauera aromatica 2-fluoro-cyclohexa-1,5-diene-1-carbonyl-CoA + methyl viologen + ADP + phosphate
-
 ?
2-hydroxy-benzoyl-CoA + reduced methyl viologen + ATP at 64% of the velocity of benzoyl-CoA Thauera aromatica 2-hydroxy-cyclohexa-1,5-diene-1-carbonyl-CoA + methyl viologen + ADP + phosphate
-
 ?
3-fluoro-benzoyl-CoA + reduced methyl viologen + ATP at 31% of the velocity of benzoyl-CoA Thauera aromatica 3-fluoro-cyclohexa-1,5-diene-1-carbonyl-CoA + methyl viologen + ADP + phosphate
-
 ?
benzoyl-CoA + reduced methyl viologen + ATP
-
 Thauera aromatica cyclohexa-1,5-diene-1-carbonyl-CoA + methyl viologen + ADP + phosphate
-
 ?
furan-2-carbonyl-CoA + reduced methyl viologen + ATP at 28% of the velocity of benzoyl-CoA Thauera aromatica ? + methyl viologen + ADP + phosphate
-
 ?
additional information no substrate: furan-3-carbonyl-CoA, pyrrole-2-carbonyl-CoA, pyridine-4-carbonyl-CoA, 4-fluoro-benzoyl-CoA Thauera aromatica ?
-
 ?
pyridine-2-carbonyl-CoA + reduced methyl viologen + ATP at 67% of the velocity of benzoyl-CoA Thauera aromatica ? + methyl viologen + ADP + phosphate
-
 ?
pyridine-4-carbonyl-CoA + reduced methyl viologen + ATP at 41% of the velocity of benzoyl-CoA Thauera aromatica ? + methyl viologen + ADP + phosphate
-
 ?
thiophene-2-carbonyl-CoA + reduced methyl viologen + ATP at 144% of the velocity of benzoyl-CoA Thauera aromatica ? + methyl viologen + ADP + phosphate
-
 ?
thiophene-3-carbonyl-CoA + reduced methyl viologen + ATP at 10% of the velocity of benzoyl-CoA Thauera aromatica ? + methyl viologen + ADP + phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Thauera aromatica

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8
-
 Thauera aromatica

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.54
-
 4-fluoro-benzoyl-CoA
-
 Thauera aromatica