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Literature summary for 1.3.7.11 extracted from

  • Sato, S.; Murakami, M.; Yoshimura, T.; Hemmi, H.
    Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product (2008), J. Bacteriol., 190, 3923-3929.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Sulfolobus acidocaldarius

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor Sulfolobus acidocaldarius the enzyme is involved in the biosynthesis of archaeal membrane lipids 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
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Organism

Organism UniProt Comment Textmining
Sulfolobus acidocaldarius Q4JA33
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-

Purification (Commentary)

Purification (Comment) Organism
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Sulfolobus acidocaldarius

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor the enzyme is involved in the biosynthesis of archaeal membrane lipids Sulfolobus acidocaldarius 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
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?
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor most preferred substrate. Since the physiological reducing agents for the enzyme remains unknown, sodium dithionite is used as acceptor Sulfolobus acidocaldarius 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
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?
3-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor activity is comparable to the activity with 2,3-di-O-geranylgeranyl-sn-glycerol 1-phosphate as substrate Sulfolobus acidocaldarius 3-O-phytyl-sn-glycerol 1-phosphate + acceptor
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?
geranylgeranyl diphosphate + reduced acceptor the enzyme does not accept NADPH. Since the physiological reducing agents for the enzyme remains unknown, sodium dithionite is used as acceptor. Geranylgeranyl diphosphate is partially reduced to phytyl diphosphate with 10% of the activity compared to the complete reduction of 2,3-di-O-phytanyl-sn-glycerol 1-phosphate Sulfolobus acidocaldarius phytyl diphosphate + acceptor
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?

Synonyms

Synonyms Comment Organism
geranylgeranyl reductase
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Sulfolobus acidocaldarius

Cofactor

Cofactor Comment Organism Structure
flavin the enzyme contains a flavin coenzyme Sulfolobus acidocaldarius

General Information

General Information Comment Organism
physiological function the enzyme is involved in the biosynthesis of archaeal membrane lipids Sulfolobus acidocaldarius