Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-2-cyano-N-(2',3-dichloro[1,1'-biphenyl]-4-yl)-3-hydroxybut-2-enamide | - |
Plasmodium falciparum | |
(2E)-N-(3-chloro-2'-methoxy[1,1'-biphenyl]-4-yl)-2-cyano-3-hydroxybut-2-enamide | - |
Plasmodium falciparum | |
(2E)-N-[2'-chloro-3-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-cyano-3-hydroxybut-2-enamide | - |
Plasmodium falciparum | |
2,8-dimethyl-N-[4-(trifluoromethyl)phenyl]pyrrolo[1,2-a]pyrimidin-4-amine | - |
Plasmodium falciparum | |
2-[[(4-chlorophenyl)methyl]sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one | - |
Plasmodium falciparum | |
5-(4-cyano-2-methyl-1H-benzimidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide | - |
Plasmodium falciparum | |
7-methyl-N-(naphthalen-2-yl)imidazo[1,2-a]pyrimidin-5-amine | - |
Plasmodium falciparum | |
7-methyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyridin-5-amine | - |
Plasmodium falciparum | |
A77-1726 | potent inhibitor | Plasmodium falciparum | |
brequinar | poor inhibitor | Plasmodium falciparum | |
leflunomide | poor inhibitor | Plasmodium falciparum | |
N-cyclopropyl-5-[4-(difluoromethoxy)-2-methyl-1H-benzimidazol-1-yl]thiophene-2-carboxamide | - |
Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Plasmodium falciparum | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-dihydroorotate + coenzyme Q | Plasmodium falciparum | - |
orotate + reduced coenzyme Q | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-dihydroorotate + coenzyme Q | - |
Plasmodium falciparum | orotate + reduced coenzyme Q | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHOD | - |
Plasmodium falciparum |
DHODase | - |
Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FMN | dependent on | Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000077 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2,8-dimethyl-N-[4-(trifluoromethyl)phenyl]pyrrolo[1,2-a]pyrimidin-4-amine | |
0.001 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2-[[(4-chlorophenyl)methyl]sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one |