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Literature summary for 1.3.5.2 extracted from
- Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria (1996), Histochem. Cell Biol., 105, 119-128.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| brequinar sodium | complete activity termination in all tissues at 0.01 mM | Bos taurus |  |
| brequinar sodium | complete activity termination in all tissues at 0.01 mM | Cavia porcellus | |
| brequinar sodium | complete activity termination in all tissues at 0.01 mM | Homo sapiens | |
| brequinar sodium | complete activity termination in all tissues at 0.01 mM | Mus musculus | |
| brequinar sodium | complete activity termination in all tissues at 0.01 mM | Rattus norvegicus | |
| brequinar sodium | complete activity termination in all tissues at 0.01 mM | Sus scrofa | |
| Orotate | - |
Bos taurus | |
| Orotate | - |
Cavia porcellus | |
| Orotate | - |
Mus musculus | |
| Orotate | - |
Rattus norvegicus | |
| Orotate | - |
Sus scrofa | |
| toltrazuril | 50% inhibition at 0.1 mM | Bos taurus | |
| toltrazuril | 50% inhibition at 0.1 mM | Cavia porcellus | |
| toltrazuril | 50% inhibition at 0.1 mM | Homo sapiens | |
| toltrazuril | 50% inhibition at 0.1 mM | Mus musculus | |
| toltrazuril | 50% inhibition at 0.1 mM | Rattus norvegicus | |
| toltrazuril | 50% inhibition at 0.1 mM | Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | inner membrane | Cavia porcellus | 5739 | - |
| mitochondrion | inner membrane | Mus musculus | 5739 | - |
| mitochondrion | inner membrane | Homo sapiens | 5739 | - |
| mitochondrion | inner membrane | Sus scrofa | 5739 | - |
| mitochondrion | inner membrane | Bos taurus | 5739 | - |
| mitochondrion | inner membrane | Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-dihydroorotate + ubiquinone | Cavia porcellus | - |
orotate + ubiquinol | - |
ir | |
| (S)-dihydroorotate + ubiquinone | Sus scrofa | - |
orotate + ubiquinol | - |
ir | |
| (S)-dihydroorotate + ubiquinone | Bos taurus | - |
orotate + ubiquinol | - |
ir | |
| (S)-dihydroorotate + ubiquinone | Mus musculus | fourth enzyme in pyrimidine synthesis | orotate + ubiquinol | - |
ir | |
| (S)-dihydroorotate + ubiquinone | Homo sapiens | fourth enzyme in pyrimidine synthesis | orotate + ubiquinol | - |
ir | |
| (S)-dihydroorotate + ubiquinone | Rattus norvegicus | fourth enzyme in pyrimidine synthesis | orotate + ubiquinol | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | Q63707 | - |
- |
| Rattus norvegicus | Q63707 | Wistar rats, both sexes, 6 month | - |
| Sus scrofa | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (S)-dihydroorotate + a quinone = orotate + a quinol | in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity | Cavia porcellus | |
| (S)-dihydroorotate + a quinone = orotate + a quinol | in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity | Mus musculus | |
| (S)-dihydroorotate + a quinone = orotate + a quinol | in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity | Homo sapiens | |
| (S)-dihydroorotate + a quinone = orotate + a quinol | in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity | Sus scrofa | |
| (S)-dihydroorotate + a quinone = orotate + a quinol | in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity | Bos taurus | |
| (S)-dihydroorotate + a quinone = orotate + a quinol | in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon | - |
Rattus norvegicus | - |
| Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
| gland | - |
Rattus norvegicus | - |
| heart | - |
Sus scrofa | - |
| heart | - |
Bos taurus | - |
| heart | - |
Rattus norvegicus | - |
| ileum | - |
Rattus norvegicus | - |
| intestine | - |
Rattus norvegicus | - |
| kidney | - |
Cavia porcellus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Sus scrofa | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| additional information | distribution in various tissues | Homo sapiens | - |
| additional information | distribution in various tissues | Rattus norvegicus | - |
| reproductive system | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Rattus norvegicus | - |
| skin | - |
Homo sapiens | - |
| skin | - |
Rattus norvegicus | - |
| stomach | - |
Rattus norvegicus | - |
| trachea | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
highest activities in ileum and colon | Rattus norvegicus |
| 0.0026 | - |
liver | Sus scrofa |
| 0.0026 | - |
kidney | Cavia porcellus |
| 0.0054 | - |
liver | Rattus norvegicus |
| 0.0054 | - |
kidney | Sus scrofa |
| 0.0066 | - |
heart | Bos taurus |
| 0.0078 | - |
heart | Sus scrofa |
| 0.015 | - |
EAT cells | Mus musculus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C, slight activity loss after freezing and storage | Cavia porcellus |
| -80°C, slight activity loss after freezing and storage | Mus musculus |
| -80°C, slight activity loss after freezing and storage | Homo sapiens |
| -80°C, slight activity loss after freezing and storage | Sus scrofa |
| -80°C, slight activity loss after freezing and storage | Bos taurus |
| -80°C, slight activity loss after freezing and storage | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-dihydroorotate + ubiquinone | - |
Cavia porcellus | orotate + ubiquinol | - |
ir | |
| (S)-dihydroorotate + ubiquinone | - |
Sus scrofa | orotate + ubiquinol | - |
ir | |
| (S)-dihydroorotate + ubiquinone | - |
Bos taurus | orotate + ubiquinol | - |
ir | |
| (S)-dihydroorotate + ubiquinone | fourth enzyme in pyrimidine synthesis | Mus musculus | orotate + ubiquinol | - |
ir | |
| (S)-dihydroorotate + ubiquinone | fourth enzyme in pyrimidine synthesis | Homo sapiens | orotate + ubiquinol | - |
ir | |
| (S)-dihydroorotate + ubiquinone | fourth enzyme in pyrimidine synthesis | Rattus norvegicus | orotate + ubiquinol | - |
ir | |
| dihydroorotate + acceptor | - |
Homo sapiens | orotate + reduced acceptor | - |
? | |
| dihydroorotate + acceptor | - |
Rattus norvegicus | orotate + reduced acceptor | - |
? | |
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