Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Tcm62 | importance in SDH assembly | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
genes encoding subunits SdhC, SdhD, and SdhB are located at 1q21,11q23, and 1p35-36.1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | the membrane domain consists of two subunits SdhC and SdhD. The membrane domain contains a bound heme b moiety at the subunit interface with SdhC and SdhD each providing one of the two axial His ligands | Homo sapiens | 5743 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | the Fe-S centers in Sdh2 consist of a 2Fe-2S center proximal to the FAD site, an adjacent 4Fe-4S center followed by a 3Fe-4S center, heme b | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + FAD | Homo sapiens | - |
fumarate + FADH2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + FAD | - |
Homo sapiens | fumarate + FADH2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the catalytic core SdhA and SdhB subunits contain the redox cofactors that participate in electron transfer to ubiquinone. Sdh1 contains the covalently bound FAD cofactor and the binding site for succinate. Sdh2 contains the three Fe-S centers that mediate electron transfer to ubiquinone in the complex of succinate-ubiquinone dehydrogenase, EC 1.3.5.1, regulation of SDH, overview.The membrane domain consists of two subunits SdhC and SdhD. The membrane domain contains a bound heme b moiety at the subunit interface with SdhC and SdhD each providing one of the two axial His ligands | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
SDH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
Fe-S center | the Fe-S centers in Sdh2 consist of a 2Fe-2S center proximal to the FAD site, an adjacent 4Fe-4S center followed by a 3Fe-4S center | Homo sapiens | |
heme b | - |
Homo sapiens |