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Literature summary for 1.3.5.1 extracted from

  • MacKenzie, E.D.; Selak, M.A.; Tennant, D.A.; Payne, L.J.; Crosby, S.; Frederiksen, C.M.; Watson, D.G.; Gottlieb, E.
    Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells (2007), Mol. Cell. Biol., 27, 3282-3289.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information inactivation of SDHD by scrambled and SDHD-targeting small interfering RNA short hairpins, Sc and Di3, expression, succinate dehydrogenase-deficient cells show cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate + ubiquinone Homo sapiens the enzyme is part of the tricarboxylic acid cycle, it is also a tumor suppressor. Succinate stabilizes and activates hypoxia-inducible factor HIFalpha and reversibly and competitively inhibits HIF-prolyl hydroxylase leading to induction of hypoxia in SDH-deficient cells, 2-oxoglutarate overcomes succinate-mediated inhibition of PHD in vitro, overview fumarate + ubiquinol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate + ubiquinone
-
Homo sapiens fumarate + ubiquinol
-
?
succinate + ubiquinone the enzyme is part of the tricarboxylic acid cycle, it is also a tumor suppressor. Succinate stabilizes and activates hypoxia-inducible factor HIFalpha and reversibly and competitively inhibits HIF-prolyl hydroxylase leading to induction of hypoxia in SDH-deficient cells, 2-oxoglutarate overcomes succinate-mediated inhibition of PHD in vitro, overview Homo sapiens fumarate + ubiquinol
-
?

Synonyms

Synonyms Comment Organism
SDH
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ubiquinone
-
Homo sapiens