Protein Variants | Comment | Organism |
---|---|---|
additional information | inactivation of SDHD by scrambled and SDHD-targeting small interfering RNA short hairpins, Sc and Di3, expression, succinate dehydrogenase-deficient cells show cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + ubiquinone | Homo sapiens | the enzyme is part of the tricarboxylic acid cycle, it is also a tumor suppressor. Succinate stabilizes and activates hypoxia-inducible factor HIFalpha and reversibly and competitively inhibits HIF-prolyl hydroxylase leading to induction of hypoxia in SDH-deficient cells, 2-oxoglutarate overcomes succinate-mediated inhibition of PHD in vitro, overview | fumarate + ubiquinol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + ubiquinone | - |
Homo sapiens | fumarate + ubiquinol | - |
? | |
succinate + ubiquinone | the enzyme is part of the tricarboxylic acid cycle, it is also a tumor suppressor. Succinate stabilizes and activates hypoxia-inducible factor HIFalpha and reversibly and competitively inhibits HIF-prolyl hydroxylase leading to induction of hypoxia in SDH-deficient cells, 2-oxoglutarate overcomes succinate-mediated inhibition of PHD in vitro, overview | Homo sapiens | fumarate + ubiquinol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SDH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ubiquinone | - |
Homo sapiens |