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Literature summary for 1.3.5.1 extracted from

  • Giancaspero, T.A.; Wait, R.; Boles, E.; Barile, M.
    Succinate dehydrogenase flavoprotein subunit expression in Saccharomyces cerevisiae - involvement of the mitochondrial FAD transporter, Flx1p (2008), FEBS J., 275, 1103-1117.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of HA-tagged Sdh1p coupled to the Escherichia coli lacZ reporter gene Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information the amount of Sdh1p decreases in an FAD transporter flx1D mutant strain, SDH1 coding sequence and the regulatory sequences located downstream of the SDH1 coding region, as well as protein import and cofactor attachment, seem to be not involved in the decrease in the amount of protein, FLX1 deletion or mutation results in a respiration-deficient phenotype, in which the activities of the mitochondrial FAD dependent-enzymes, lipoamide dehydrogenase and succinate dehydrogenase, are reduced, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Saccharomyces cerevisiae 5739
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
x * 70000, about, HA-tagged Sdh1p, SDS-PAGE, x * 66000, cleaved HA-tagged Sdh1p, SDS-PAGE Saccharomyces cerevisiae
70000
-
x * 70000, about, HA-tagged Sdh1p, SDS-PAGE, x * 66000, cleaved HA-tagged Sdh1p, SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae succinate dehydrogenase flavoprotein subunit Sdh1p is bound by the mitochondrial FAD transporter, Flx1p, a member of the mitochondrial carrier family responsible for FAD transport in Saccharomyces cerevisiae, FLX1p controls SDH activity by regulating the amount of flavinylated Sdh1p, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
gene SDH1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information succinate dehydrogenase flavoprotein subunit Sdh1p is bound by the mitochondrial FAD transporter, Flx1p, a member of the mitochondrial carrier family responsible for FAD transport in Saccharomyces cerevisiae, FLX1p controls SDH activity by regulating the amount of flavinylated Sdh1p, overview Saccharomyces cerevisiae ?
-
?

Subunits

Subunits Comment Organism
? x * 70000, about, HA-tagged Sdh1p, SDS-PAGE, x * 66000, cleaved HA-tagged Sdh1p, SDS-PAGE Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
succinate dehydrogenase flavoprotein subunit Sdh1p
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein Saccharomyces cerevisiae