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Literature summary for 1.3.5.1 extracted from
- Identification of the heme Axial ligands in the cytochrome b562 of the Saccharomyces cerevisiae succinate dehydrogenase (2004), J. Biol. Chem., 279, 9432-9439.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C78A | mutation in Sdh4 subunit, 94% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
| C78H | mutation in Sdh4 subunit, 53% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
| C85A | mutation in Sdh4 subunit, 94% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
| H106A | mutation in Sdh3 subunit, 78% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
| H113A | mutation in Sdh3 subunit, 61% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
| H30A | mutation in Sdh3 subunit, 97% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
| H37A | mutation in Sdh4 subunit, 100% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
| H46A | mutation in Sdh3 subunit, 45% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
| H46D | mutation in Sdh3 subunit, 47% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
| H84A | mutation in Sdh3 subunit, 97% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
| H99A | mutation in Sdh4 subunit, 75% of wild-type kcat for 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone reduction | Saccharomyces cerevisiae |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0034 | - |
2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone | 22°C | Saccharomyces cerevisiae |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Saccharomyces cerevisiae | 16020 | - |
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + ubiquinone | Saccharomyces cerevisiae | - |
fumarate + ubiquinol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone | - |
Saccharomyces cerevisiae | fumarate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol | - |
? | |
| succinate + ubiquinone | - |
Saccharomyces cerevisiae | fumarate + ubiquinol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SDH | - |
Saccharomyces cerevisiae |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 60 | - |
2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone | 22°C | Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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