Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Morine | 50% inhibition at 0.00018 mM | Berberis wilsoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0013 | - |
(S)-Tetrahydrojatrorrhizine | - |
Berberis wilsoniae | |
0.0267 | - |
(S)-canadine | - |
Berberis wilsoniae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | firmly bound to enzyme protein, involved in activity | Papaver somniferum | |
Fe2+ | firmly bound to enzyme protein, involved in activity | Berberis wilsoniae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100000 | - |
- |
Berberis wilsoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-tetrahydroberberine + 2 O2 | Berberis wilsoniae | 7,14-dehydroberberinium as intermediate, protoberberine biosynthesis | protoberberine + 2 H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Berberis wilsoniae | - |
var. subcaulialata | - |
Papaver somniferum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Berberis wilsoniae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-canadine + O2 | - |
Berberis wilsoniae | ? | - |
? | |
(S)-tetrahydroberberine + 2 O2 | - |
Berberis wilsoniae | berberine + 2 H2O2 | - |
? | |
(S)-tetrahydroberberine + 2 O2 | 7,14-dehydroberberinium as intermediate, protoberberine biosynthesis | Berberis wilsoniae | protoberberine + 2 H2O2 | - |
? | |
(S)-tetrahydrojatrorrhizine + O2 | - |
Berberis wilsoniae | ? | - |
? | |
additional information | specific for tetrahydroprotoberberines of the (S)-configuration, C-14 and N-7 of tetrahydroprotoberberines are oxidized | Berberis wilsoniae | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.9 | - |
- |
Berberis wilsoniae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | - |
Berberis wilsoniae |