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Literature summary for 1.3.3.6 extracted from

  • Jiang, Z.; Thorpe, C.
    Acyl-CoA oxidase from Candida tropicalis (1983), Biochemistry, 22, 3752-3758.
    View publication on PubMed
Search for more literature for 1.3.3.6

Inhibitors

Inhibitors Comment Organism Structure
3,4-pentadienoyl-CoA rapid, irreversible Candida tropicalis
3-octynoyl-CoA irreversible Candida tropicalis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
 8 * 75000, SDS-PAGE Candida tropicalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + O2 Candida tropicalis
-
 trans-2,3-dehydroacyl-CoA + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Candida tropicalis
-
 pK 233, inducible by growth on alkanes
-

Reaction

Reaction Comment Organism Reaction ID
acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 anti-elimination of pro-2R and pro-3R hydrogens of acyl-CoA Candida tropicalis
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Candida tropicalis

Storage Stability

Storage Stability Organism
-20°C, pH 7.4, 2 months Candida tropicalis
4°C, pH 7.4, 2 months, 20% loss of activity Candida tropicalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoheptadecyldethio-CoA + O2
-
 Candida tropicalis ?
-
 ?
acyl-CoA + O2
-
 Candida tropicalis trans-2,3-dehydroacyl-CoA + H2O2
-
 ?
palmitoyl-CoA + O2
-
 Candida tropicalis 2-trans-hexadecenoyl-CoA + H2O2
-
 ?

Subunits

Subunits Comment Organism
octamer 8 * 75000, SDS-PAGE Candida tropicalis

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein Candida tropicalis
FAD 8 mol FAD per mol of enzyme, 1 mol FAD per mol of subunit Candida tropicalis