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Literature summary for 1.3.3.4 extracted from

  • Ferreira, G.C.; Andrew, T.L.; Karr, S.W.; Dailey, H.A.
    Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex (1988), J. Biol. Chem., 263, 3835-3839.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bilirubin competitive Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion lipid bilayer of inner membrane Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoporphyrinogen-IX + 3 O2 Mus musculus penultimate step of heme and chlorophyll biosynthesis protoporphyrin-IX + 3 H2O2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoporphyrinogen-IX + 3 O2
-
Mus musculus protoporphyrin-IX + 3 H2O2
-
?
protoporphyrinogen-IX + 3 O2 penultimate step of heme and chlorophyll biosynthesis Mus musculus protoporphyrin-IX + 3 H2O2
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.025
-
bilirubin
-
Mus musculus