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Literature summary for 1.3.3.4 extracted from
- Kinetic properties of the membrane-bound human liver mitochondrial protoporphyrinogen oxidase (1985), Arch. Biochem. Biophys., 242, 206-212.
General Stability
| General Stability | Organism |
|---|---|
| dithiothreitol stabilizes better than glutathione | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cobalt-protoporphyrin | - |
Homo sapiens |  |
| heme | 0.001 mM cause 25% inhibition | Homo sapiens | |
| metalloporphyrin | Mn- and Co-protoporphyrin, weak inhibition by Cd-, Ni- and Fe-protoporphyrin, 5 min preincubation | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00016 | - |
protoporphyrinogen-IX | pH 7.2 | Homo sapiens | |
| 0.00033 | - |
protoporphyrinogen-IX | pH 8.0 | Homo sapiens | |
| 0.0005 | - |
Mesoporphyrinogen-IX | biphasic curve, second Km: 0.004 | Homo sapiens | |
| 0.00055 | - |
protoporphyrinogen-IX | pH 8.5 | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | membrane bound | Homo sapiens | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protoporphyrinogen-IX + 3 O2 | Homo sapiens | penultimate step of heme and chlorophyll biosynthesis | protoporphyrin-IX + 3 H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| mesoporphyrinogen-IX + 3 O2 | - |
Homo sapiens | mesoporphyrin-IX + 3 H2O2 | - |
? | |
| protoporphyrinogen-IX + 3 O2 | - |
Homo sapiens | protoporphyrin-IX + 3 H2O2 | - |
? | |
| protoporphyrinogen-IX + 3 O2 | penultimate step of heme and chlorophyll biosynthesis | Homo sapiens | protoporphyrin-IX + 3 H2O2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
- |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0008 | - |
cobalt-protoporphyrin | noncompetitive | Homo sapiens | |
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