Application | Comment | Organism |
---|---|---|
medicine | function of CPO in heme biosynthesis is apparently conserved between zebrafish and human, suggesting that CPO-MO-injected zebrafish embryos might be a useful in vivo assay system to measure the biological activity of human CPO mutations | Danio rerio |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of zebrafish CPO using anti-sense morpholinos leads to a significant suppression of hemoglobin production without apparent reduction of blood cells, injection of human CPO RNA, but not a mutant CPO RNA similar to a mutant responsible for a hereditary coproporphyria, restores hemoglobin production in the CPO-MO-injected embryos, expression of CPO in the ICM is severely suppressed in both vlad tepes/gata1 mutants and in biklf-MO-injected embryos | Danio rerio |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
zebrafish strain AB or Riken-Wako | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Danio rerio | - |
additional information | intermediate cell mass | Danio rerio | - |
Synonyms | Comment | Organism |
---|---|---|
CPO | - |
Danio rerio |