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Literature summary for 1.3.3.15 extracted from

  • Lobo, S.A.; Scott, A.; Videira, M.A.; Winpenny, D.; Gardner, M.; Palmer, M.J.; Schroeder, S.; Lawrence, A.D.; Parkinson, T.; Warren, M.J.; Saraiva, L.M.
    Staphylococcus aureus haem biosynthesis: characterisation of the enzymes involved in final steps of the pathway (2015), Mol. Microbiol., 97, 472-487.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21STAR DE3 pLysS cells Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme exhibits resistence to acifluorfen Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrinogen III + O2 Staphylococcus aureus
-
coproporphyrin III + H2O
-
?
protoporphyrinogen IX + O2 Staphylococcus aureus
-
protoporphyrin IX + H2O
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+ Sepharose column chromatography Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen III + O2
-
Staphylococcus aureus coproporphyrin III + H2O
-
?
additional information the enzyme cannot oxidize protoporphyrinogen IX Staphylococcus aureus ?
-
?
protoporphyrinogen IX + O2
-
Staphylococcus aureus protoporphyrin IX + H2O
-
?

Synonyms

Synonyms Comment Organism
hemY
-
Staphylococcus aureus
proto'gen oxidase
-
Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Staphylococcus aureus