Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli and in host strain | Staphylococcus aureus |
Protein Variants | Comment | Organism |
---|---|---|
E275K | strong decrease in enzyme activity, thinner cell walls than wild type strain | Staphylococcus aureus |
G251D | strong decrease in enzyme activity, thinner cell walls than wild type strain | Staphylococcus aureus |
G78D | strong decrease in enzyme activity, thinner cell walls than wild type strain | Staphylococcus aureus |
S243F | strong decrease in enzyme activity, thinner cell walls than wild type strain | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH | Staphylococcus aureus | essential for cell growth, functions in bacterial peptidoglycan biosynthesis | UDP-N-acetyl-3-D-muramate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | Q54A20 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH | - |
Staphylococcus aureus | UDP-N-acetyl-3-D-muramate + NADP+ | - |
? | |
UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH | essential for cell growth, functions in bacterial peptidoglycan biosynthesis | Staphylococcus aureus | UDP-N-acetyl-3-D-muramate + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | bound to protein | Staphylococcus aureus | |
NADPH | - |
Staphylococcus aureus |