Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.9 extracted from

  • Joshi, S.; Kumar, S.; Patil, S.; Vijayakumar, M.; Kulkarni, V.; Nadagouda, M.; Badiger, A.; Lherbet, C.; Aminabhavi, T.
    Chemical synthesis, molecular modeling and pharmacophore mapping of new pyrrole derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth (2019), Med. Chem. Res., 28, 1838-1863 .
No PubMed abstract available
Search for more literature for 1.3.1.9

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
1-([1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl)-4-methylpiperazine i.e. BM-212 Mycobacterium tuberculosis
additional information not inhibited by N-(4-phenyl-1,3-thiazol-2-yl)-4-(1H-pyrrol-1-yl)benzamide Mycobacterium tuberculosis
N-(2,6-dichlorophenyl)-4-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide 31% inhibition at 0.05 mM, 35% inhibition at 0.005 mM Mycobacterium tuberculosis
N-(2-aminophenyl)-4-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide 12% inhibition at 0.05 mM, 35% inhibition at 0.005 mM Mycobacterium tuberculosis
N-(4-aminophenyl)-4-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide 30% inhibition at 0.05 mM, 35% inhibition at 0.005 mM Mycobacterium tuberculosis
N-benzyl-4-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide 12% inhibition at 0.05 mM, 35% inhibition at 0.005 mM Mycobacterium tuberculosis
N-[2-methyl-5-phenyl-3-([4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methyl)-1H-pyrrol-1-yl]pyridine-4-carboxamide i.e. LL3858 Mycobacterium tuberculosis
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-(1H-pyrrol-1-yl)benzamide 25% inhibition at 0.05 mM, 35% inhibition at 0.005 mM Mycobacterium tuberculosis
N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-4-(2,5-dimethyl-1Hpyrrol-1-yl)benzamide 38% inhibition at 0.05 mM, 35% inhibition at 0.005 mM Mycobacterium tuberculosis
N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-4-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide 38% inhibition at 0.05 mM, 35% inhibition at 0.005 mM Mycobacterium tuberculosis
N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-4-(1H-pyrrol-1-yl)benzamide 30% inhibition at 0.05 mM, 35% inhibition at 0.005 mM Mycobacterium tuberculosis
opiniazide
-
 Mycobacterium tuberculosis
phtivazid
-
 Mycobacterium tuberculosis
triclosan more than 99% inhibition at 0.05 mM Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trans-2-enoyl-[acyl-carrier protein] + NADH Mycobacterium tuberculosis
-
 acyl-[acyl-carrier protein] + NAD+
-
 ?
trans-2-enoyl-[acyl-carrier protein] + NADH Mycobacterium tuberculosis H37Rv
-
 acyl-[acyl-carrier protein] + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WGR1
-
-
Mycobacterium tuberculosis H37Rv P9WGR1
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography, and Superdex 200 gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-2-dodecenoyl-CoA + NADH + H+
-
 Mycobacterium tuberculosis dodecanoyl-CoA + NAD+
-
 ?
trans-2-dodecenoyl-CoA + NADH + H+
-
 Mycobacterium tuberculosis H37Rv dodecanoyl-CoA + NAD+
-
 ?
trans-2-enoyl-[acyl-carrier protein] + NADH
-
 Mycobacterium tuberculosis acyl-[acyl-carrier protein] + NAD+
-
 ?
trans-2-enoyl-[acyl-carrier protein] + NADH
-
 Mycobacterium tuberculosis H37Rv acyl-[acyl-carrier protein] + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
enoyl acyl carrier protein reductase
-
 Mycobacterium tuberculosis
ENR
-
 Mycobacterium tuberculosis
InhA
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism main enzyme for type II fatty acid synthesis Mycobacterium tuberculosis