Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.9 extracted from

  • Zhu, L.; Lin, J.; Ma, J.; Cronan, J.; Wang, H.
    Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase (2010), Antimicrob. Agents Chemother., 54, 689-698.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.9

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.691
-
 crotonyl-[acyl-carrier protein] pH 7.0, temperature not specified in the publication Pseudomonas aeruginosa
0.704
-
 trans-2-decenoyl-[acyl-carrier protein] pH 7.0, temperature not specified in the publication Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9HZP8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
crotonyl-[acyl-carrier protein] + NADH + H+
-
 Pseudomonas aeruginosa butyryl-[acyl-carrier protein] + NAD+
-
 ?
trans-2-decenoyl-[acyl-carrier protein] + NADH + H+
-
 Pseudomonas aeruginosa decanoyl-[acyl-carrier protein] + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
FabV
-
 Pseudomonas aeruginosa
PA2950
-
 Pseudomonas aeruginosa

General Information

General Information Comment Organism
physiological function isoform FabV confers triclosan resistance on Pseudomonas aeruginosa. Upon deletion of the fabV gene, the mutant strain becomes more than 2000fold more sensitive to triclosan than the wild-type strain. Enzyme functionally replaces Escherichia coli fabI in vivo and renders Escherichia coli resistant to triclosan Pseudomonas aeruginosa