Literature summary for 1.3.1.9 extracted from

Tipparaju, S.K.; Muench, S.P.; Mui, E.J.; Ruzheinikov, S.N.; Lu, J.Z.; Hutson, S.L.; Kirisits, M.J.; Prigge, S.T.; Roberts, C.W.; Henriquez, F.L.; Kozikowski, A.P.; Rice, D.W.; McLeod, R.L.
Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase (2010), J. Med. Chem., 53, 6287-6300.

Crystallization (Commentary)

Crystallization (Comment)	Organism
enzyme in complex with NAD+ and 19, X-ray diffraction structure determination and analysis at 2.7 A resolution	Toxoplasma gondii

Inhibitors

Inhibitors	Comment	Organism
(2E)-3-(6-aminopyridin-3-yl)-N-(4-methoxyphenyl)prop-2-enamide	-	Toxoplasma gondii
(2E)-3-(6-aminopyridin-3-yl)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]prop-2-enamide	-	Toxoplasma gondii
(2E)-3-[6-(acetylamino)pyridin-3-yl]-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]prop-2-enamide	-	Toxoplasma gondii
(2E)-N-(2-aminobenzyl)-3-(6-aminopyridin-3-yl)prop-2-enamide	-	Toxoplasma gondii
(2E,4E)-N-[3-chloro-4-(4-chloro-2-hydroxyphenoxy)phenyl]hexa-2,4-dienamide	-	Toxoplasma gondii
(2E,4E)-N-[4-(2,4-dichlorophenoxy)-3-hydroxyphenyl]hexa-2,4-dienamide	-	Toxoplasma gondii
1-(2-chlorobenzyl)-4-[(4-methoxybenzyl)oxy]pyridin-2(1H)-one	-	Toxoplasma gondii
1-(3-chloro-4-nitrophenyl)-1,3-dihydro-2H-benzimidazol-2-one	-	Toxoplasma gondii
1-(4-nitrobenzoyl)-1,3-dihydro-2H-benzimidazol-2-one	-	Toxoplasma gondii
1-(4-nitrobenzyl)-1,3-dihydro-2H-benzimidazol-2-one	-	Toxoplasma gondii
1-ethoxy-1-oxopropan-2-yl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate	-	Toxoplasma gondii
1-[(4-nitrophenyl)sulfonyl]-1,3-dihydro-2H-benzimidazol-2-one	-	Toxoplasma gondii
2-(2,4-dinitrophenoxy)-5-propylphenol	-	Toxoplasma gondii
2-(2-chloro-4-nitrophenoxy)-5-propylphenol	-	Toxoplasma gondii
2-(3-chlorophenoxy)-5-propylphenol	-	Toxoplasma gondii
2-(3-nitrophenoxy)-5-propylphenol	-	Toxoplasma gondii
2-(4-aminophenoxy)-5-propylphenol	-	Toxoplasma gondii
2-(4-nitrophenoxy)-5-propylphenol	-	Toxoplasma gondii
2-(biphenyl-4-yloxy)-5-chlorophenol	-	Toxoplasma gondii
2-amino-N-(5-chloro-2-phenoxyphenyl)pyridine-3-carboxamide	-	Toxoplasma gondii
2-[3-(2-hydroxyethyl)phenoxy]-5-propylphenol	-	Toxoplasma gondii
3-chloro-4-(2,6-dihydroxy-4-propylphenoxy)benzoic acid	-	Toxoplasma gondii
3-chloro-4-(2-hydroxy-4-propylphenoxy)benzonitrile	crystal and binding structure determination, overview	Toxoplasma gondii
3-chloro-4-(2-hydroxy-6-methoxy-4-propylphenoxy)benzonitrile	-	Toxoplasma gondii
4-(2,6-dihydroxy-4-propylphenoxy)benzamide	-	Toxoplasma gondii
4-(2,6-dihydroxy-4-propylphenoxy)benzonitrile	-	Toxoplasma gondii
4-(4-hydroxyphenoxy)benzene-1,3-diol	-	Toxoplasma gondii
4-(benzyloxy)-1-(2-chloro-4-nitrobenzyl)pyridin-2(1H)-one	-	Toxoplasma gondii
4-(benzyloxy)-1-(2-chlorobenzyl)pyridin-2(1H)-one	-	Toxoplasma gondii
4-phenoxybenzene-1,3-diol	-	Toxoplasma gondii
4-[3-(9H-carbazol-9-yl)propoxy]-1-(2-chlorobenzyl)pyridin-2(1H)-one	-	Toxoplasma gondii
4-{[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl}-3-chlorobenzamide	-	Toxoplasma gondii
4-{[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl}-3-chlorobenzoic acid	-	Toxoplasma gondii
4-{[4-(benzyloxy)-2-oxopyridin-1(2H)-yl]methyl}-3-chlorobenzonitrile	-	Toxoplasma gondii
5-chloro-2-(2,4-dichlorophenoxy)phenol	-	Toxoplasma gondii
5-chloro-2-(2,4-dichlorophenoxy)phenyl 2,2-dimethylpropanoate	-	Toxoplasma gondii
5-chloro-2-(2-nitrophenoxy)phenol	-	Toxoplasma gondii
5-chloro-2-(4-hydroxyphenoxy)phenol	-	Toxoplasma gondii
5-chloro-2-(4-nitrophenoxy)phenol	-	Toxoplasma gondii
5-chloro-2-(pyrazin-2-yloxy)phenol	-	Toxoplasma gondii
5-chloro-2-(pyridin-3-yloxy)phenol	-	Toxoplasma gondii
5-chloro-2-phenoxyaniline	-	Toxoplasma gondii
5-chloro-2-phenoxyphenol	-	Toxoplasma gondii
5-propyl-2-[4-(2H-tetrazol-5-yl)phenoxy]benzene-1,3-diol	-	Toxoplasma gondii
additional information	drug design, synthesis, and evaluation of the compounds concerning antiparasite activity and toxicity to host cells, overview	Toxoplasma gondii
N-(3-aminophenyl)-2-(4-nitrophenoxy)acetamide	-	Toxoplasma gondii
N-(4-methoxyphenyl)-2-(4-nitrophenoxy)acetamide	-	Toxoplasma gondii
N-(5-chloro-2-phenoxyphenyl)-2,2-dimethylpropanamide	-	Toxoplasma gondii
N-[2-(4-chloro-2-hydroxyphenoxy)phenyl]acetamide	-	Toxoplasma gondii
N-[4-(4-chloro-2-hydroxyphenoxy)phenyl]acetamide	-	Toxoplasma gondii
N-[5-(4-chloro-2-hydroxyphenoxy)pyridin-2-yl]acetamide	-	Toxoplasma gondii
N1-phenylbenzene-1,2,4-triamine	-	Toxoplasma gondii
triclosan	-	Toxoplasma gondii
[3-(2-hydroxy-4-propylphenoxy)phenyl]boronic acid	-	Toxoplasma gondii

Organism

Organism	UniProt	Comment	Textmining
Toxoplasma gondii	Q6UCJ9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
tachyzoite	-	Toxoplasma gondii	-

Synonyms

Synonyms	Comment	Organism
enoyl reductase	-	Toxoplasma gondii
ENR	-	Toxoplasma gondii

General Information

General Information	Comment	Organism
physiological function	enoyl reductase, ENR, a type II fatty acid synthase enzyme essential in parasites but not present in host animals	Toxoplasma gondii